Propylamine hydrochloride → HCID 178441274, compound
Reaction equation
[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:27])([CH3:26])[CH3:25])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=O)[C:14]1([CH3:22])[CH3:21])=[O:12])[CH2:2][CH2:3][CH3:4].Cl.[CH2:29]([NH2:32])[CH2:30][CH3:31]>>[CH2:1]([C:5]1=[CH:6][N:7]([C:24]([CH3:25])([CH3:26])[CH3:27])[S:8]/[C:9]/1=[N:10]\[C:11]([C@:13]1([CH3:23])[CH2:17][CH2:16][C@H:15]([C:18]([NH:32][CH2:29][CH2:30][CH3:31])=[O:20])[C:14]1([CH3:21])[CH3:22])=[O:12])[CH2:2][CH2:3][CH3:4]Participants
3
Procedure
The product from Example 173 and propylamine hydrochloride (Aldrich) were processed using the method described in Example 178 to afford the title compound. 1H NMR 1H NMR (DMSO-d6) δ 0.48 (s, 3H), 0.83 (t, J=7.3 Hz, 3H), 0.90 (t, J=7.3 Hz, 3H), 1.19 (s, 3H), 1.23 (s, 3H), 1.26-1.43 (m, 5H), 1.56 (s, 9H), 1.56-1.67 (m, 3H), 1.96-2.09 (m, 1H), 2.62-2.69 (m, 3H), 2.72-2.95 (m, 2H), 3.06-3.17 (m, 1H), 7.53-7.57 (m, 1H), 8.50 (s, 1H). MS (ESI+) m/z 436 (M+H)+. Anal. calcd. for C24H41N3O2S: C, 66.16; H, 9.49; N, 9.65. Found: C, 65.76; H, 9.51; N, 9.68.
Sources & evidence
- ORD record
- ord-93dd4c3f07fa4d8b955c553561bfdd82
- Source dataset
- uspto-grants-2013_08