Hydrazine → 4-Methyl-1,3-thiazole-2-carbohydrazide

HRID 1889049Notes

Reaction equation

HRID 1889049 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([C:7]([O:9]CC)=O)[S:5][CH:6]=1.[NH2:12][NH2:13]>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([C:7]([NH:12][NH2:13])=[O:9])[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 567306Ethyl 4-methyl-1,3-thiazole-2-carboxylate

Product 1

HCID 112289374-Methyl-1,3-thiazole-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 4-methyl-1,3-thiazole-2-carboxylate (I120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 18 hours
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-98724bebacf9490c9529b3bed35afff4
Source dataset
uspto-grants-2013_08
Patent number
US08501946B2

Reaction notes

Loading…