Thieno[2,3-b]pyridin-2-ylmethanol → Thieno[2,3-b]pyridin-2-ylmethanamine

Reaction equation

[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH2:10]O.S1C2C(=[N:16]C=CC=2)C=C1CN>>[S:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH2:10][NH2:16]

Participants

Reactant 2

HCID 7162092Thieno[2,3-b]pyridin-2-ylmethanol

HCID 67305714Thieno[3,2-b]pyridin-2-ylmethanamine

Product 1

HCID 67304785Thieno[2,3-b]pyridin-2-ylmethanamine

Procedure

Intermediate E was prepared from thieno[2,3-b]pyridine-2-ylmethanol (E-2) following similar procedures for synthesizing intermediate C from C-4, as described above. MS (m/z): 165 (M+1)+.

Sources & evidence

ORD record: ord-c2b5aa9d36254cc0b1ac68ba20655ee3
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507487B2

Reaction notes

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