methyl 1-ethyl-1H-thieno[3,2-c]pyrazole-5-carboxylate → (1-Ethyl-1H-thieno[3,2-c]pyrazol-5-yl)methanamine chloride

Reaction equation

[Cl-:1].C([N:4]1[CH:8]=[C:7]2[S:9][C:10]([CH2:12][NH3+:13])=[CH:11][C:6]2=[N:5]1)C.[CH2:14](N1C2C=C(C(OC)=O)SC=2C=N1)[CH3:15].Cl.S1C2C=CN=CC=2C=C1CN>>[Cl-:1].[CH2:14]([N:5]1[C:6]2[CH:11]=[C:10]([CH2:12][NH2:13])[S:9][C:7]=2[CH:8]=[N:4]1)[CH3:15]

Participants

Reactant 3

HCID 67305514methyl 1-ethyl-1H-thieno[3,2-c]pyrazole-5-carboxylate

HCID 67306703Thieno[3,2-c]pyridin-2-ylmethanamine hydrochloride

HCID 86671433(2-Ethyl-2H-thieno[3,2-c]pyrazol-5-yl)methanaminium chloride

Product 1

HCID 86671434(1-Ethyl-1H-thieno[3,2-c]pyrazol-5-yl)methanamine chloride

Procedure

Intermediate G′ was prepared from methyl 1-ethyl-1H-thieno[3,2-c]pyrazole-5-carboxylate (G′-3) following similar procedures for synthesizing intermediate D from D-2, as described above. MS (m/z): 182 (M+1)+.

Sources & evidence

ORD record: ord-2248acaed2da4934a4a8be94cf3c428e
Source dataset: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08507487B2

Reaction notes

Loading…