Sodium Hydroxide → HCID 58550626, compound
Reaction equation
[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C@:3]21[CH2:43][C:13]1[CH:14]=[C:15]3[C:20](=[CH:21][C:12]=1[CH2:11]2)[N:19]=[CH:18][C:17]([CH2:22][NH:23][CH2:24][CH:25]([C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)[CH2:26][NH:27][C:28]1([C:33]([O:35]C)=[O:34])[CH2:32][CH2:31][CH2:30][CH2:29]1)=[CH:16]3.[OH-].[Na+]>CO>[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C@:3]21[CH2:43][C:13]1[CH:14]=[C:15]3[C:20](=[CH:21][C:12]=1[CH2:11]2)[N:19]=[CH:18][C:17]([CH2:22][NH:23][CH2:24][CH:25]([C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1)[CH2:26][NH:27][C:28]1([C:33]([OH:35])=[O:34])[CH2:29][CH2:30][CH2:31][CH2:32]1)=[CH:16]3Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Into a solution of methyl 1-{[3-({[(7S)-2′-oxo-1′,2′,6,8-tetrahydrospiro[cyclopenta[g]quinoline-7,3′-pyrrolo[2,3-b]pyridin]-3-yl]methyl}amino)-2-phenylpropyl]amino}cyclopentanecarboxylate from Step E (0.136 g, 0.236 mmol) in methanol (2 mL) was added NaOH (0.472 mL, 1 M in water). The solution is then allowed to stir for 18 h at ambient temperature. Additional NaOH (0.472 mL, 1 M in water) was then added to the reaction, which was completed after another 24 h of stirring. The solution was then concentrated in vacuo and neutralized by addition of HCl (0.944 mL, 1 M in water). The resulting precipitate was filtered to yield the title compound. MS: m/z=562 (M+1).