2-Nitrotoluene-4-sulphonamide → 3-Amino-4-methylbenzenesulfonamide
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-])=O>CO.[Pt]=O>[NH2:12][C:3]1[CH:4]=[C:5]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:6]=[CH:7][C:2]=1[CH3:1]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 4-methyl-3-nitrobenzenesulfonamide (2.1 g) and platinum oxide (210 mg) in methanol (50 ml) was stirred under hydrogen atmosphere at room temperature for 6 hours. The insoluble compound was filtered out, then the filtrate was concentrated. The residue was recrystallized from hexane/acetone to obtain the title compound (1.23 g).
Workup
- filtrationThe insoluble compound was filtered out
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from hexane/acetone
Sources & evidence
- ORD record
- ord-7f65a313541e4aba8d131d5a2cc5fca4
- Source dataset
- uspto-grants-2013_08
- Patent number
- US08507714B2
Reaction notes
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