Salicylaldehyde → p-Pentadecanoxybenzaldehyde

Participants

Reaction Conditions

Reaction Steps

In a 100 ml four-necked flask, 2.79 g (42.3 mM) of 85 wt % potassium hydroxide was suspended in 30 ml of dimethylformamide, and 10 ml of a dimethylformamide solution containing 5.28 g (43.2 mM) of hydroxybenzaldehyde was added thereto dropwise while maintaining the system at 20° C. or lower, followed by aging at 30° C. for 1 hour. To the system was added 9.58 g (32.9 mM) of 1-bromopentadecane, followed by aging at 70° C. for 21 hours. The reaction mixture was dispersed in water and extracted with toluene. The extract was washed with water and concentrated to give 11.03 g of a slightly colored viscous liquid. Recrystallization from hexane gave 8.91 g of p-pentadecanoxybenzaldehyde (purity: 98.3%).

Provenance & Evidence