Octahydrocyclopenta(c)pyrrole → 2-{1-[(4s,5r)-2-(6-Tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-1-(hexahydro-cyclopenta[c]pyrrol-2-yl)-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Octahydrocyclopenta(c)pyrrole	HCID 110688	—
Reactant	{1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid	HCID 57670162	—
Product	2-{1-[(4s,5r)-2-(6-Tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-1-(hexahydro-cyclopenta[c]pyrrol-2-yl)-ethanone	HCID 57669937	—

Reaction Steps

In a manner analogous to the method described in example 163, {1-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperidin-4-yl}-acetic acid was reacted with 3,4-(1,3-propanediyl)pyrrolidine (BetaPharm) to give the title product. LC-MS (ES+) 758 [(M+H)+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08513239B2
Source dataset	uspto-grants-2013_08
ORD ID	ord-8fbd2a0b23bb44668765e9924fd5a9ee
Source note	uspto-grants-2013_08