Bromopyruvic Acid → 2-(3,4-Dichloroanilino)-1,3-thiazole-4-carboxylic acid

HRID 1895399Notes

Reaction equation

HRID 1895399 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH2:12])=[S:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:14][C:15](=O)[C:16]([OH:18])=[O:17]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[S:11][CH:14]=[C:15]([C:16]([OH:18])=[O:17])[N:12]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 70684Bromopyruvic AcidHCID 710776N-(3,4-Dichlorophenyl)thiourea

Product 1

HCID 242138602-(3,4-Dichloroanilino)-1,3-thiazole-4-carboxylic acidYield 95.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(3,4-Dichloro-phenylamino)-thiazole-4-carboxylic acid (275 mg) was prepared according to General Procedure B using (3,4-dichloro-phenyl)-thiourea (220 mg) and 3-bromo-2-oxo-propionic acid (200 mg) in methanol (2 mL). The crude product was used in a subsequent step without further purification.

Workup

  1. customThe crude product was used in a subsequent step without further purification

Sources & evidence

ORD record
ord-e04cea16fea34da191b2528d6ca902ee
Source dataset
uspto-grants-2013_08
Patent number
US08513430B2

Reaction notes

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