Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate → 5-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

HRID 1895968

Reaction equation

HRID 1895968 reaction equation
C[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[C:9][CH:10]=[C:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.[C:17](C1C=C(C#CC=C2CCN(C(OC(C)(C)C)=O)CC2)C=NC=1)#[N:18]>>[NH:14]1[CH2:13][CH2:12][C:11](=[CH:10][C:9]#[C:8][C:4]2[CH:5]=[CH:6][C:7]([C:2]#[N:3])=[N:18][CH:17]=2)[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 25183829Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Product 1

HCID 875497035-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

Procedure

The title compounds were prepared following the procedure described for the compound of Example 3 but starting respectively from the compounds of Example 45 and 46 instead of the compound of Example 2. The crudes were used in the next step without further purification.

Workup

  1. customThe crudes were used in the next step without further purification

Sources & evidence

ORD record
ord-77ce2b0e472a4b3587e90754b2777946
Source dataset
uspto-grants-2013_08
Patent number
US08518916B2

Linked notes

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