Thionyl Chloride → 6-Fluoro-2-naphthoyl chloride

HRID 1897577

Reaction equation

HRID 1897577 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.S(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:17])=[O:14])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27827886-Fluoro-2-naphthoic acid

Product 1

HCID 866748346-Fluoro-2-naphthoyl chloride

Procedure

6-fluoro-2-naphthoic acid (2 g, 10.52 mmol) was stirred in thionyl chloride (21.03 ml) at 80° C. for 4 h in pressure vessel. The mixture was cooled and concentrated. The acid chloride was dried and used as is for next step.

Workup

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. dry with materialThe acid chloride was dried

Sources & evidence

ORD record
ord-9bce67345cf24d389ebf4192955b9154
Source dataset
uspto-grants-2013_08
Patent number
US08519134B2

Linked notes

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