Toluene → 4-(2',4',6'-Trifluorophenyl)-carbethoxysemicarbazide

HRID 1902897

Reaction equation

HRID 1902897 reaction equation
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[C:10]=1[NH2:11].[C:18]([NH:23][NH:24][C:25](Cl)=[O:26])([O:20][CH2:21][CH3:22])=[O:19]>C(OCC)(=O)C.C1(C)C=CC=CC=1>[F:8][C:9]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[C:10]=1[NH:11][C:25](=[O:26])[NH:24][NH:23][C:18]([O:20][CH2:21][CH3:22])=[O:19]

Participants

5

Reactant 3

HCID 1140TolueneHCID 677652,4,6-TrifluoroanilineHCID 84905Ethyl 3-(chloroformyl)carbazate

Product 1

HCID 129043774-(2',4',6'-Trifluorophenyl)-carbethoxysemicarbazide

Reagents, catalysts & solvents 1

HCID 21584019Toluene ethylacetateSolvent

Procedure

A toluene solution of 2,4,6-trifluoroaniline is reacted with 2-carbethoxyhydrazinecarbonyl chloride as described above in Example 1b, mp 177°-178° (ethyl acetate/toluene).

Sources & evidence

ORD record
ord-3574e8679a7842c585f3b7dcf2e120cf
Source dataset
uspto-grants-1982_12
Patent number
US04366320

Linked notes

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