Acetic Anhydride → HCID 13787480, compound

Reaction equation

[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:3]1[CH3:14].[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[C:15]([NH:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:3]1[CH3:14])(=[O:17])[CH3:16]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 128619201-Benzyl-2-methylpyrrolidin-3-amine

Product 1

HCID 13787480HCID 13787480, compound

Procedure

3-Amino-1-benzyl-2-methylpyrrolidine [Japanese Laid-Open Patent Publication No. 22699/1980] was allowed to react with acetic anhydride to give 3-acetylamino-1-benzyl-2-methylpyrrolidine, m.p. 51°-54° C. This compound was hydrogenated catalytically in the presence of 5% palladium-carbon to give 3-acetylamino-2-methylpyrrolidine as an oil.

Sources & evidence

ORD record: ord-d2d23e0ab188463983aa3cdad4d638ee
Source dataset: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04649144

Reaction notes

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