p-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde oxime → 4-Chloro-benzaldehyde oxime

HRID 1905930

Reaction equation

HRID 1905930 reaction equation
Cl.NNC(N[N:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)=N.FC(F)([O:21]C1C=CC(C=NO)=CC=1)C(F)F>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH:8]=[N:7][OH:21])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 85531600p-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde oximeHCID 178479532HCID 178479532, compound

Product 1

HCID 2191584-Chloro-benzaldehyde oxime

Procedure

Using a similar procedure, 1-amino-3-p{[p-(1,1,2,2-tetrafluoroethoxy)benzylidene]amino}guanidine hydrochloride (white solid, mp 205°-212° C.); 1-amino-3-{p-(trifluoroethoxy)benzylidene]amino}guanidine hydrochloride (white powder; mp 235°-238° C.); and 1-amino-3-(p-chlorobenzylideneamino)guanidine hydrochloride may be prepared. The second products of the reactions, p-(1,1,2,2-tetrafluoroethoxy)benzaldehyde oxime (pinkish white solid, mp 47°-53.5° C.); α,α,α-trifluoro-p-anilaldehyde oxime (off-white solid, mp 46°-49.5° C.) and p-chlorbenzaldehyde oxime may also be isolated from the reactions.

Sources & evidence

ORD record
ord-7595c8efa3f048ef868d25ee45b7ffca
Source dataset
uspto-grants-1987_03
Patent number
US04649148

Linked notes

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