1-Bromopropane → HCID 13823145, compound

Reaction equation

[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:7]=1.Br[CH2:15][CH2:16][CH3:17]>>[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH2:9][N:10]([CH2:15][CH2:16][CH3:17])[CH2:11][CH2:12][CH:13]=2)[N:7]=1

Participants

Reactant 2

HCID 78401-Bromopropane

HCID 1382315056541-06-1

Product 1

HCID 13823145HCID 13823145, compoundYield 65%

Procedure

The procedure described in Example 1 was repeated, using the N-methyl-4-(3-pyridinyl)-2-thiazolamine prepared in Example 14 and an excess of 1-bromopropane as the reactants. The title compound was purified by column chromatography (65% yield) and converted to its HCl salt by the procedure of Example 2. The resulting salt (mp 138° C.) contained 1.25 molecules of HCl and one molecule of water.

Workup

customThe title compound was purified by column chromatography (65% yield)

Sources & evidence

ORD record: ord-287302bec2034127b7f7c11ba9431164
Source dataset: uspto-grants-1987_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04650805

Reaction notes

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