1-(2-Methoxyphenyl)piperazine → HCID 13729383, compound

HRID 1906438

Reaction equation

HRID 1906438 reaction equation
[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>C(O)C>[C:1]([C:4]1[O:5][C:6]2[C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][N:29]3[CH2:28][CH2:27][N:26]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=4[O:19][CH3:18])[CH2:31][CH2:30]3)=[CH:11][CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 137294032-Carbamoyl-7-(2,3-epoxypropoxy)benzofuran

Product 1

HCID 13729383HCID 13729383, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was suspended 1.2 g (0.005 mole) of 2-carbamoyl-7-(2,3-epoxypropoxy)benzofuran in 15 ml of ethanol, and thereto 1.1 g (0.0055 mole) of 1-(2-methoxyphenyl)piperazine was added. Thereafter, the mixture was refluxed with heating for 2 hours. After completion of the reaction, the solvent was distilled away from the reaction mixture under reduced pressure, and then the resultant residue was crystallized from chloroform and petroleum ether.

Workup

  1. temperatureThereafter, the mixture was refluxed
  2. temperaturewith heating for 2 hours
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled away from the reaction mixture under reduced pressure
  5. customthe resultant residue was crystallized from chloroform and petroleum ether

Sources & evidence

ORD record
ord-b04fffa17ff647cf8475d77b2c6e1a69
Source dataset
uspto-grants-1987_03
Patent number
US04652566

Linked notes

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