2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol

HRID 1908256

Reaction equation

HRID 1908256 reaction equation
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]

Participants

4

Reactant 2

HCID 15811772-Amino-1-(4-fluorophenyl)ethanoneHCID 4311764Sodium borohydride

Product 1

HCID 98272-Amino-1-(4-fluorophenyl)ethan-1-olYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.

Workup

  1. concentrationconcentrated to dryness
  2. additionThe residue was diluted with EtOAc
  3. washwashed with a satd
  4. dry with materialNH4Cl solution before drying (Na2SO4)
  5. concentrationconcentrating

Sources & evidence

ORD record
ord-3de15211aafd4142a970ccbc6622e103
Source dataset
uspto-grants-2013_12
Patent number
US08598202B2

Linked notes

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