8-Bromo-1,6-naphthyridine → 4-Cyano-3-[1,6]naphthyridin-8-yl-benzoic acid methyl ester
Reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[CH3:12][O:13][C:14](=[O:32])[C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[C:17](B2OC(C)(C)C(C)(C)O2)[CH:16]=1>>[CH3:12][O:13][C:14](=[O:32])[C:15]1[CH:20]=[CH:19][C:18]([C:21]#[N:22])=[C:17]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]3[C:11]=2[N:10]=[CH:9][CH:8]=[CH:7]3)[CH:16]=1Participants
3
Procedure
Using, 8-bromo-[1,6]naphthyridine (1 mol. eq.) and 4-cyano-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester (2.0 mol. eq.) as starting materials, the product was prepared using General procedure L (Suzuki) to give the title compound. MS(ESI) m/z 290.1 (M+H)+.
Workup
- customthe product was prepared