1,4-Dioxane hydrochloride → HCID 44818810, compound
Reaction equation
C[O:2][C:3](=[O:28])[CH2:4][CH2:5][CH2:6][N:7]1[CH2:11][CH2:10][CH2:9][C@@H:8]1[CH2:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)=[CH:16][CH:15]=1.Cl.O1CCOCC1>>[ClH:27].[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([O:20][C:17]2[CH:18]=[CH:19][C:14]([O:13][CH2:12][C@H:8]3[CH2:9][CH2:10][CH2:11][N:7]3[CH2:6][CH2:5][CH2:4][C:3]([OH:28])=[O:2])=[CH:15][CH:16]=2)=[CH:22][CH:23]=1Participants
3
Procedure
Following the general procedure for Example 18, the product from step 1 (0.80 g 1.99 mmol) was treated with a 1:1 mixture of concentrated HCl/dioxane (36 mL) to afford the title compound (0.21 g, 26%) as a white solid.
Sources & evidence
- ORD record
- ord-a8c7144870944941a72291a1907f9ade
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08598359B2