Formamidine acetate → HCID 178518231, compound
Reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([O:9]CC)=O.C(O)(=O)C.[CH:16](N)=[NH:17]>CCO>[CH:5]1[N:4]=[C:3]2[C:7]([N:17]=[CH:16][NH:1][N:2]2[CH:6]=1)=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of ethyl 1-amino-1H-imidazole-2-carboxylate (C-4) (800 mg, 5.16 mmol, 1.0 eq) and formamidine acetate (2.68 g, 25.78 mmol, 5.0 eq) in EtOH (100 mL) is stirred at reflux overnight. The resulting mixture is cooled to RT. The solid is collected by filtration, rinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3), and then dried in vacuo to afford the product, imidazo[1,2-f][1,2,4]triazin-4-ol (C-5).
Workup
- temperatureat reflux overnight
- filtrationThe solid is collected by filtration
- washrinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3)
- customdried in vacuo
Sources & evidence
- ORD record
- ord-1dae880d81a544f488751c7688749de1
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08604032B2
Reaction notes
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