Dimethylformamide diethylacetal → HCID 59186962, compound

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[N:6][CH:7]=1.C(O[CH:17](OCC)[N:18]([CH3:20])[CH3:19])C>>[Br:1][C:2]1[CH:3]=[C:4](/[C:8](=[CH:17]/[N:18]([CH3:20])[CH3:19])/[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[N:6][CH:7]=1

Participants

Reactant 2

HCID 70913Dimethylformamide diethylacetal

HCID 54116619Ethyl 2-(5-bromopyridin-3-yl)acetate

Product 1

HCID 59186962HCID 59186962, compound

Procedure

5.1 g (20.8 mmol) of the compound from Example 8A in 7.1 ml (6.2 g, 41.8 mmol) of dimethylformamide diethyl acetal are heated at 100° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure.

Workup

temperatureAfter cooling
concentrationthe mixture is concentrated under reduced pressure

Sources & evidence

ORD record: ord-80e3d7f797304050959edbf9d9291729
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609698B2

Reaction notes

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