o-Fluoroacetophenone → HCID 79117049, compound

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([OH:12])[CH2:9][C:10]#[N:11].F[C:14]1C=CC=CC=1C(=O)C>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([OH:12])([CH3:14])[CH2:9][C:10]#[N:11]

Participants

Reactant 2

HCID 96744o-Fluoroacetophenone

HCID 13616591HCID 13616591, compound

Product 1

HCID 79117049HCID 79117049, compound

Procedure

3-(2-Fluoro-phenyl)-3-hydroxy-butyronitrile was prepared by the same procedure of 3-(2-fluoro-phenyl)-3-hydroxy-propionitrile from 1-(2-fluoro-phenyl)-ethanone in example 6.

Sources & evidence

ORD record: ord-8561c96cfa1d45c9965b83810e4c9cca
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609849B1

Reaction notes

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