Ammonium Chloride → HCID 66769369, compound
Reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7]#[N:8])[N:6]=1.C[O-].[Na+].[Cl-].[NH4+:13]>CO>[ClH:1].[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH2:13])=[NH:8])[N:6]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
10 mmol 2-chloro-4-cyanothiazole was dissolved in 10 ml anhydrous methanol, and 10 mmol sodium methoxide was added. Upon complete reaction of the starting materials, 20 mmol ammonium chloride was added, to carry out reaction in closed state for 12 hr. The reaction product was filtered to remove inorganic salt, and then the resultant filtrate was concentrated to obtain 2-chloro-4-thiazolformamidine hydrochloride.
Workup
- additionwas added
- customreaction in closed state for 12 hr
- filtrationThe reaction product was filtered
- customto remove inorganic salt
- concentrationthe resultant filtrate was concentrated
Sources & evidence
- ORD record
- ord-4e03d73f121542eea25dfef6ebb1b23e
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08168642B2
Reaction notes
Loading…