Azane;hydrate → 2-Methylthiazole-5-carboxamide
Reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:7]([O:9]C)=O)=[CH:5][N:6]=1.O.[NH3:12]>>[CH3:1][C:2]1[S:3][C:4]([C:7]([NH2:12])=[O:9])=[CH:5][N:6]=1Participants
3
Procedure
1.4 g Methyl 2-methylthiazol-5-carboxylate was added to 25 ml ammonia water, to carry out reaction at room temperature for 3 hr. The reaction product was cooled down, filtered, and washed with water to obtain 0.95 g a white powdery solid (73%) with mp 202-205 (C.
Workup
- customreaction at room temperature for 3 hr
- temperatureThe reaction product was cooled down
- filtrationfiltered
- washwashed with water
Sources & evidence
- ORD record
- ord-c38b706d80a24896bfb56f94447db64e
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08168642B2
Reaction notes
Loading…