4-Isocyanato-2-(trifluoromethyl)benzonitrile → 4-[2,5-Dioxo-4-(4-hydroxyphenyl)-4-methylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
Reaction equation
[NH2:1][C:2]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)([CH3:7])[C:3]([O:5]C)=O.[C:15]([C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[O:25])=[CH:19][C:18]=1[C:26]([F:29])([F:28])[F:27])#[N:16]>>[O:25]=[C:24]1[NH:1][C:2]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)([CH3:7])[C:3](=[O:5])[N:23]1[C:20]1[CH:21]=[CH:22][C:17]([C:15]#[N:16])=[C:18]([C:26]([F:27])([F:28])[F:29])[CH:19]=1Participants
3
Procedure
This product is prepared as in Example 5, starting from 10.71 g of methyl 2-amino-2-(4-hydroxyphenyl)propionate using 4-cyano-3-trifluoromethylphenyl isocyanate. 16.83 g of product are obtained (Yd=82%).
Workup
- customThis product is prepared as in Example 5