Formamide → 6-Methoxyquinazolin-4-OL
Reaction equation
[NH2:1][C:2]1(N)[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:3]1[C:4](O)=[O:5].[CH:14]([NH2:16])=O>C(O)C>[CH3:12][O:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[CH:14][NH:16][C:4]2=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 1.025 mmoles of 2-amino-5-methoxy anthranilic acid add 6.14 mmoles of formamide and microwave reaction mixture for 20 mins at 160° C. After cooling the solid was diluted with 10 mL ethanol, the mixture was heated to reflux and allowed to cool slowly. The solid obtained was filtered and washed with cold ethanol and vacuum dried to give the title compound in 50% yield.
Workup
- temperatureAfter cooling the solid
- temperaturethe mixture was heated
- temperatureto reflux
- temperatureto cool slowly
- customThe solid obtained
- filtrationwas filtered
- washwashed with cold ethanol and vacuum
- customdried
Sources & evidence
- ORD record
- ord-1960e3c9a1b64c64befcad614858dc45
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08168788B2
Reaction notes
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