1,4-Dioxane hydrochloride → N,N-bis(1H-imidazol-2-ylmethyl)-N'-(piperidin-4-ylmethyl)urea
Reaction equation
CN(C)S([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:30][C:31]1[N:32](S(N(C)C)(=O)=O)[CH:33]=[CH:34][N:35]=1)[C:13]([NH:15][CH2:16][CH:17]1[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]1)=[O:14])(=O)=O.Cl.O1CCOCC1>>[NH:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][N:12]([CH2:30][C:31]1[NH:32][CH:33]=[CH:34][N:35]=1)[C:13]([NH:15][CH2:16][CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:14]Participants
3
Conditions
- Temperature
- 60 °C
Procedure
To the compound (3.00 g) obtained in Example 9, 4N hydrogen chloride/dioxane (15 mL) was added. The reaction solution was stirred at 60° C. for 15 hours. The reaction solution was concentrated under reduced pressure. The residue was dissolved in methanol (20 mL) and a carbonate resin (trade name: MP-Carbonate, manufactured by Argonaut Co., product number: 800267, 10 g) was added, followed by stirring at room temperature for 3 hours. After the resin was removed by filtration, the filtrate was concentrated under reduced pressure. The title compound was obtained without purifying the residue.