HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → Ziprasidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ziprasidone Hydrochloride | HCID 219099 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole | HCID 2772144 | — |
| Reactant | 5-(2-Chloroethyl)-6-chlorooxindole | HCID 10609474 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | Ziprasidone | HCID 60854 | — |
Reaction Steps
U.S. Pat. No. 4,831,031 discloses a process for the preparation of ziprasidone hydrochloride, which involves refluxing N-(1,2-benzisothiazol-3-yl)piperazine with 5-(2-chloroethyl)-6-chloro-oxindole in methyl isobutyl ketone in the presence of sodium iodide and sodium carbonate for about 40 hours followed by column chromatographic purification of the product to get ziprasidone base which is dissolved in methylene chloride and treated with ethereal hydrogen chloride to get ziprasidone hydrochloride salt. The salt is washed with acetone and the product is dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08178674B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-a1fe5bcacab64580aac065d315eeeb4c |
| Source note | uspto-grants-2012_05 |