Formamidine acetate → 6-(furan-2-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-ol
Reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[O:8][CH:9]=[CH:10][CH:11]=2)[NH:4][C:3]=1[C:12]([O:14]CC)=O.C(O)(=O)C.[CH:21](N)=[NH:22]>C(O)C>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[NH:4][C:3]2[C:12](=[O:14])[NH:22][CH:21]=[N:1][C:2]=2[CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of ethyl 3-amino-5-(2-furyl)-1H-pyrrole-2-carboxylate (2.58 g) in ethanol (35 mL) was added formamidine acetate (1.83 g), and the mixture was heated under reflux for 18 hrs. After cooling to room temperature, the precipitated solid was collected by filtration, washed with ethanol, and dried under reduced pressure at 60° C. to give the title compound (2.26 g).
Workup
- temperaturethe mixture was heated
- temperatureunder reflux for 18 hrs
- filtrationthe precipitated solid was collected by filtration
- washwashed with ethanol
- customdried under reduced pressure at 60° C.
Sources & evidence
- ORD record
- ord-0892badb54c14fb6b553e8368b245712
- Source dataset
- uspto-grants-2012_05
- Patent number
- US08178543B2
Reaction notes
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