Oxycodone → Morphine Oxycodone
Reaction equation
[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]>>[CH:1]1[C:17]2[CH2:16][C@H:15]3[N:18]([CH2:20][CH2:21][C@@:7]45[C@H:14]3[CH:13]=[CH:12][C@H:10]([OH:11])[C@@H:8]4[O:9][C:5]([C:6]=25)=[C:3]([OH:4])[CH:2]=1)[CH3:19].[CH3:22][N:23]1[C@@H:40]2[CH2:41][C:28]3[CH:29]=[CH:30][C:31]([O:43][CH3:44])=[C:32]4[O:33][C@H:34]5[C:35]([CH2:37][CH2:38][C@:39]2([OH:42])[C@:26]5([C:27]=34)[CH2:25][CH2:24]1)=[O:36]Participants
3
Reactant 2
Product 1
Procedure
Objective The main objective was to compare the ventilatory responses to hypoxia and hypercarbia following one hour intravenous infusions of (1) morphine 15 mg, or (2) oxycodone 15 mg, or (3) morphine 10 mg+oxycodone 5 mg, or (4) oxycodone 10 mg+morphine 5 mg, or (5) morphine 7.5 mg+oxycodone 7.5 mg. Each infusion was administered over 1 h and was designated by its respective composition as M15, M10—05, M7.5—07.5, M5—010 or 015.
Workup
- waitEach infusion was administered over 1 h