1,4-Dioxane hydrochloride → HCID 66879498, compound

Reaction equation

C(OC([N:8]1[C@H:12]([C:13]([NH2:15])=[O:14])[CH2:11][S:10][CH2:9]1)=O)(C)(C)C.[ClH:16].O1CCOCC1>>[ClH:16].[S:10]1[CH2:11][C@@H:12]([C:13]([NH2:15])=[O:14])[NH:8][CH2:9]1

Participants

Reactant 2

HCID 204431481,4-Dioxane hydrochloride

HCID 51340398HCID 51340398, compound

Product 1

HCID 66879498HCID 66879498, compoundYield 99%

Procedure

(4R)-3-(tert-Butyloxycarbonyl)thiazolidine-4-carboxamide (8.6 g, 37.1 mmol) was dissolved in 4M HCl/dioxan (50 ml). After 1 h at room temperature the solvent was evaporated in vacuo to give a white solid identified as the title compound (6.2 g, 36.8 mmol, 99%).

Workup

customAfter 1 h at room temperature the solvent was evaporated in vacuo
customto give a white solid

Sources & evidence

ORD record: ord-17174d8349a4427c9777b79fa6c59211
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08183280B2

Reaction notes

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