4-Methylbenzaldehyde → 3-(p-Methylphenyl)propanal

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][CH:10]=[O:11])[CH2:4][CH2:3]1.CC1C=CC(C=O)=CC=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]=[O:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 77254-Methylbenzaldehyde

HCID 582625174-Methyl cyclohexanepropanal

Product 1

HCID 648123-(p-Methylphenyl)propanal

Procedure

4-Methyl cyclohexanepropanal was similarly prepared as described in Examples I and II. First, 4-methyl benzaldehyde (140 g, commercially available from Mitsubishi Gas Chemical America, Inc.) was used to obtain 3-(4-methyl-phenyl)-propionaldehyde (130 g) with a boiling point of 120° C. at a pressure of 21 mmHg 3-(4-Methyl-phenyl)-propionaldehyde (180 g) was consequently used to provide 4-methyl cyclohexanepropanal (104 g) with a boiling point of 112° C. at a pressure of 24 mmHg

Sources & evidence

ORD record: ord-8161592e23ed4177b2470fc2684c2046
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188023B2

Reaction notes

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