Aniline → HCID 59152268, compound

Reaction equation

FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:16]=[C:17]([O:20][CH2:21][C:22]([NH:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[O:24])[S:18][CH:19]=2)=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6115Aniline

HCID 68536712HCID 68536712, compound

Product 1

HCID 59152268HCID 59152268, compound

Procedure

The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-yloxy]-acetic acid trifluoroacetic acid salt and 50.7 mg (0.54 mmol) of aniline. Yield: 7.6 mg.

Sources & evidence

ORD record: ord-a9cc84e2d7fa4aeaaf6495de5729ebc4
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08188291B2

Reaction notes

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