Sodium Hydroxide → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid
Reaction equation
C([O:3][C:4](=[O:20])[CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])=[CH:11][CH:12]=1)C.[OH-].[Na+]>C(O)C>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH2:5][C:4]([OH:20])=[O:3])=[CH:12][CH:11]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 47.5 °C
Procedure
11.5 g (0.042 mol) of 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid ethyl ester were dissolved in 230 ml ethanol, 7.7 ml of a 32% sodium hydroxide solution were added, and the mixture stirred at 45 to 50° C. for 1 h. After evaporation to dryness, the remaining solid was taken up in 100 ml of water, the pH was adjusted to 2.5 to 3 with 2 N hydrochloric acid, and the precipitated product was filtered off with suction. The solid was rinsed with water and dried. Yield 10.0 g.