Azetidine → 1-(Azetidin-1-yl)-2-[4-(4-fluoro-phenyl)-thiazol-2-ylamino]-ethanone trifluoroacetic acid salt
Reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([NH:20][CH2:21][C:22]([OH:24])=O)[S:18][CH:19]=2)=[CH:11][CH:10]=1.[NH:25]1[CH2:28][CH2:27][CH2:26]1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:25]1([C:22](=[O:24])[CH2:21][NH:20][C:17]2[S:18][CH:19]=[C:15]([C:12]3[CH:11]=[CH:10][C:9]([F:8])=[CH:14][CH:13]=3)[N:16]=2)[CH2:28][CH2:27][CH2:26]1Participants
3
Procedure
The title compound was prepared analogously as described in Example 30(d) from 100 mg (0.27 mmol) of [4-(4-fluoro-phenyl)-thiazol-2-ylamino]-acetic acid trifluoroacetic acid salt and 31.2 mg (0.54 mmol) of azetidine. Yield: 27 mg.
Sources & evidence
- ORD record
- ord-fbd17571786747b9bbddb0ec7fa0fddd
- Source dataset
- uspto-grants-2012_05
- DOI