HCID 18738447, compound → 3-((dimethylamino)sulfonyl]-2(R)-methylpropionic acid
Reaction equation
[CH3:1][N:2]([CH3:19])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([O:10]CC1C=CC=CC=1)=[O:9])(=[O:5])=[O:4]>C(O)(=O)C.[Pd]>[CH3:19][N:2]([CH3:1])[S:3]([CH2:6][C@H:7]([CH3:18])[C:8]([OH:10])=[O:9])(=[O:4])=[O:5]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A 100 mL Fisher/Porter vessel was charged with 1.4 g of benzyl 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionate in 30 mL acetic acid with a catalytic amount of 10% Pd—C. The reaction was hydrogenated at 50 psi for 24 hours, filtered through Celite and concentrated in vacuo. The residue was azeotroped with toluene then concentrated in vacuo to afford 900 mg of 3-[(dimethylamino)sulfonyl]-2(R)-methylpropionic acid which was used without further purification.
Workup
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
- customThe residue was azeotroped with toluene
- concentrationthen concentrated in vacuo
Sources & evidence
- ORD record
- ord-686b36f125654dfea51f842c304663dd
- Source dataset
- uspto-grants-2002_05
- Patent number
- US06384036B1
Reaction notes
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