Reaction equation
F[C:2]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:16]=[CH:15][C:11]2[O:12][CH2:13][O:14][C:10]=2[CH:9]=1)=[O:5].[NH2:24][CH:25]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:26][OH:27]>>[OH:27][CH2:26][CH:25]([NH:24][C:2]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:16]=[CH:15][C:11]2[O:12][CH2:13][O:14][C:10]=2[CH:9]=1)=[O:5])[CH2:28][CH2:29][CH2:30][CH3:31]Participants
3
Procedure
2-[1-(1-Hydroxymethyl)pentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide (203 mg) was prepared from 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide (200 mg) and 2-amino-1-hexanol (221 mg) in a similar manner to that of Example 1(1) as yellow crystals. mp 112-115° C.
Sources & evidence
- ORD record
- ord-8d06bd17e3e846aeb4b6862159c45256
- Source dataset
- uspto-grants-2002_05
- Patent number
- US06384080B1
Linked notes
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