(3-Chloroprop-1-yn-1-yl)benzene → (2S,3R,6S)-2,6-Dimethyl-4-[4-(3-phenyl-prop-2-ynyloxy)-benzenesulfonyl]-morpholine-3-carboxylic acid methyl ester

HRID 1935343

Reaction equation

HRID 1935343 reaction equation
Cl[CH2:2][C:3]#[C:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:11][O:12][C:13]([C@H:15]1[C@H:20]([CH3:21])[O:19][C@@H:18]([CH3:22])[CH2:17][N:16]1[S:23]([C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)(=[O:25])=[O:24])=[O:14]>>[CH3:11][O:12][C:13]([C@H:15]1[C@H:20]([CH3:21])[O:19][C@@H:18]([CH3:22])[CH2:17][N:16]1[S:23]([C:26]1[CH:27]=[CH:28][C:29]([O:32][CH2:2][C:3]#[C:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH:30][CH:31]=1)(=[O:25])=[O:24])=[O:14]

Participants

3

Reactant 2

HCID 287343(3-Chloroprop-1-yn-1-yl)benzeneHCID 12016690(2S,3R,6S)-4-(4-Hydroxy-benzenesulfonyl)-2,6-dimethyl-morpholine-3-carboxylic acid methyl ester

Product 1

HCID 12016683(2S,3R,6S)-2,6-Dimethyl-4-[4-(3-phenyl-prop-2-ynyloxy)-benzenesulfonyl]-morpholine-3-carboxylic acid methyl ester

Procedure

The title compound was prepared in a manner similar to the preparation in Preparation 3 from (3-chloro-prop-1-ynyl)-benzene and (2S,3R,6S)4-(4-hydroxy-benzenesulfonyl)-2,6-dimethyl-morpholine-3-carboxylic acid methyl ester. Calculated for C23H25NO6S (M+H): 444.14. Found: 444.0.

Sources & evidence

ORD record
ord-e359a953fb9d470a967ba8dd49c4bf79
Source dataset
uspto-grants-2002_05
Patent number
US06387901B1

Linked notes

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