3-Chloropropionic acid → 3-[4,7-Bis(2-carboxyethyl)-1,4,7-triazonan-1-yl]propanoic acid

Reaction equation

[NH:1]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[CH2:11][CH2:12][C:13]([OH:15])=[O:14]>>[C:13]([CH2:12][CH2:11][N:1]1[CH2:9][CH2:8][N:7]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:6][CH2:5][N:4]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH2:3][CH2:2]1)([OH:15])=[O:14]

Participants

Reactant 2

HCID 78993-Chloropropionic acid

HCID 1883181,4,7-Triazacyclononane

Product 1

HCID 3939053-[4,7-Bis(2-carboxyethyl)-1,4,7-triazonan-1-yl]propanoic acid

Procedure

From 1,4,7-triazacyclononane (1.1.3), 3-chloropropionic acid and base.

Sources & evidence

ORD record: ord-4435b51d3ab84012b01a1601f00541bb
Source dataset: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06387891B2

Reaction notes

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