Thionyl Chloride → 3-(4-Methoxyphenyl)-2-phenylpropionyl chloride

HRID 1935735

Reaction equation

HRID 1935735 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1.S(Cl)([Cl:22])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([Cl:22])=[O:12])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 977393-(4-Methoxyphenyl)-2-phenylpropionic acid

Product 1

HCID 111403233-(4-Methoxyphenyl)-2-phenylpropionyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(4-Methoxyphenyl)-2-phenylpropanoic acid (12.5 g, 0.049 mol) was converted to its acid chloride by treatment with thionyl chloride (8.2 ml) in dry dichloromethane (75 ml) at 40° C. Excess thionyl chloride and dichloromethane were evaporated off. The crude product was used in the next step without purification.

Workup

  1. customExcess thionyl chloride and dichloromethane were evaporated off
  2. customThe crude product was used in the next step without purification

Sources & evidence

ORD record
ord-8330fac80b4f466ab997698fb37b3886
Source dataset
uspto-grants-2002_05
Patent number
US06388090B2

Linked notes

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