alpha,beta-Diphenyl acrylic acid → 2,3-Diphenylpropionic acid

HRID 1935739

Reaction equation

HRID 1935739 reaction equation
[C:1]1([C:7](=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].C(O)C>[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 66677alpha,beta-Diphenyl acrylic acid

Product 1

HCID 187442,3-Diphenylpropionic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Palladium on charcoal (0.8 g) was added to a solution of α-phenylcinnamic acid (10.0 g, 0.0445 mol) in ethanol (200 ml). The mixture was hydrogenated at ambient temperature. The mixture was filtered through Celite, and the solvent was evaporated.

Workup

  1. customwas hydrogenated at ambient temperature
  2. filtrationThe mixture was filtered through Celite
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-33cead44eac44e468313dedb95cecb85
Source dataset
uspto-grants-2002_05
Patent number
US06388090B2

Linked notes

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