alpha,beta-Diphenyl acrylic acid → 2,3-Diphenylpropionic acid
Reaction equation
[C:1]1([C:7](=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[Pd].C(O)C>[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1Participants
4
Reagents, catalysts & solvents 2
Procedure
10% Palladium on charcoal (0.8 g) was added to a solution of α-phenylcinnamic acid (10.0 g, 0.0445 mol) in ethanol (200 ml). The mixture was hydrogenated at ambient temperature. The mixture was filtered through Celite, and the solvent was evaporated.
Workup
- customwas hydrogenated at ambient temperature
- filtrationThe mixture was filtered through Celite
- customthe solvent was evaporated
Sources & evidence
- ORD record
- ord-33cead44eac44e468313dedb95cecb85
- Source dataset
- uspto-grants-2002_05
- Patent number
- US06388090B2
Reaction notes
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