2-Amino-1-dimethylaminopropane → HCID 22609855, compound

HRID 1936788

Reaction equation

HRID 1936788 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([C:26]4[O:30][C:29]([CH:31]=O)=[CH:28][CH:27]=4)[CH:24]=3)[N:19]=[CH:18][N:17]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:33][N:34]([CH3:39])[CH2:35][CH:36]([NH2:38])[CH3:37]>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[C:23]([C:26]4[O:30][C:29]([CH2:31][NH:38][CH:36]([CH3:37])[CH2:35][N:34]([CH3:39])[CH3:33])=[CH:28][CH:27]=4)[CH:24]=3)[N:19]=[CH:18][N:17]=2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 990272-Amino-1-dimethylaminopropaneHCID 219519665-(4-(4-Benzyloxy-phenylamino)-quinazolin-6-yl)-furan-2-carbaldehyde

Product 1

HCID 22609855HCID 22609855, compound

Procedure

5-(4-(4-Benzyloxy-phenylamino)-quinazolin-6-yl)-furan-2-carbaldehyde and N,N-dimethyl-1,2-propanediamine were reacted in an analogous manner to Example 10 to give the title compound; δH [2H6]-DMSO 9.83 (1H, b,), 8.70 (1H, s), 8.42 (1H, s), 8.10 (1H, d), 7.73 (1H, d), 7.64 (2H, d), 7.50-7.28 (5H, m), 7.02 (2H, d), 6.99 (1H, s), 6.52 (1H, d), 5.10 (2H, s), 3.93-3.70 (2H, m), 2.04 (9H, m), 0.92 (3H, m); m/z 508 (M+1)+.

Sources & evidence

ORD record
ord-ae85ce33ad7e48e1ae2ac6ad48e7fc68
Source dataset
uspto-grants-2002_05
Patent number
US06391874B1

Linked notes

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