Cyclohexane → 1-(2-Bromophenyl)ethan-1-ol

Interesterification was carried out by using 5 g of Lipase P of Pseudomonas fluorescens origin (a product of Amano Pharmaceutical Co., Ltd.), 10 g of (R,S)-1-2-(bromophenyl)ethanol, 30 g of tribehen and 450 ml of cyclohexane at 50° C. for 72 hours in the same manner as in Example 8. The water content of the reaction system was 0.01% by weight, and 90% of the lipase particles had a particle size of 30 to 50 μm. Gas chromatography of the reaction mixture revealed that 48 mol % of (R,S)-1-(2-bromophenyl)ethanol had been converted to 1-(2-bromophenyl)ethyl behenate. The reaction mixture was treated in the same manner as in Example 8, and the residue was subjected to simple distillation at 110° C. and 5 mmHg to recover unreacted (S)-(-)-1-(2-bromophenyl)ethanol (yield: 82%; chemical purity: 99.9%; optical purity: 98% ee).

1. additionThe reaction mixture was treated in the same manner as in Example 8
2. distillationthe residue was subjected to simple distillation at 110° C.

ORD record

ord-34c2dfe66184439aa444fd21605461f1

Source dataset

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05696299