N-(4-oxo-butyl)-benzamide → 1,3-Dihydro-isoindole-2-carboxylic acid (4-oxo-butyl)-amide
Reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)=[O:8].O=CCCCNC(=O)C1C=CC=CC=1>>[O:1]=[CH:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]([N:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)=[O:8]Participants
3
Procedure
1,3-Dihydro-isoindole-2-carboxylic acid (4-oxo-butyl)-amide (27C) is prepared from 27B as described for 1E. The crude product is obtained in almost quantitative yield.
Sources & evidence
- ORD record
- ord-6f0c773f18044ac8a4e31ecdb91d83f2
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08389555B2
Reaction notes
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