N-(4-oxo-butyl)-benzamide → (4-Naphthoyl-piperazin-1-yl)-acetaldehyde

Reaction equation

[C:1]1([C:11]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]2)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O=CCCCNC(=O)C1C=CC=CC=1>>[C:1]1([C:11]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH:20]=[O:21])[CH2:15][CH2:14]2)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 10352536N-(4-oxo-butyl)-benzamide

HCID 433908862-(4-Naphthoyl-piperazin-1-yl)-ethanol

Product 1

HCID 86651320(4-Naphthoyl-piperazin-1-yl)-acetaldehyde

Procedure

(4-Naphthoyl-piperazin-1-yl)-acetaldehyde (39C) is prepared from 39B as described for 1E.

Sources & evidence

ORD record: ord-9a79c6af3ed547048bfaabbd2c1cae42
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08389555B2

Reaction notes

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