5-Amino-2-(trifluoromethyl)pyridine → 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:5]=C[C:7]=1[C:8]([F:11])([F:10])[F:9].FC(F)(F)C1[N:23]=CC(N)=CC=1>>[F:9][C:8]([F:11])([F:10])[C:7]1[N:23]=[CH:5][C:4]([S:12]([Cl:15])(=[O:14])=[O:13])=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 27377445-Amino-2-(trifluoromethyl)pyridine

HCID 221487553-Chloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

Product 1

HCID 455943116-(Trifluoromethyl)pyridine-3-sulfonyl chloride

Procedure

The title compound was prepared by a method analogous to the method used to prepare Intermediate 39 using 6-(trifluoromethyl)pyridin-3-amine as the starting material. LCMS (R—SO3−)=226.2.

Sources & evidence

ORD record: ord-b783f24728a646a48c1bbd35ad8de7fb
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394858B2

Reaction notes

Loading…