1-(5-Chloropent-1-yn-1-yl)-4-nitrobenzene → 1-(5-Bromopent-1-yn-1-yl)-4-nitrobenzene

Reaction equation

[Br:1]CCCC#CC1C=CC(NC(=O)C(F)(F)F)=CC=1.Cl[CH2:21][CH2:22][CH2:23][C:24]#[C:25][C:26]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[CH:28][CH:27]=1>>[Br:1][CH2:21][CH2:22][CH2:23][C:24]#[C:25][C:26]1[CH:31]=[CH:30][C:29]([N+:32]([O-:34])=[O:33])=[CH:28][CH:27]=1

Participants

Reactant 2

HCID 547714241-(5-Chloropent-1-yn-1-yl)-4-nitrobenzene

HCID 56923688N-(4(5-bromopent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 252338641-(5-Bromopent-1-yn-1-yl)-4-nitrobenzene

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 40, using Intermediate 41 as a substrate. ES/MS calcd. for C11H11BrNO2+ 268.0. Found m/z=268.1 (M+H)+.

Sources & evidence

ORD record: ord-0a8a0702e93246b69f9362e0143313f1
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08394829B2

Reaction notes

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