1-(3,4-Dinitrobenzyl)-4-methylpiperazine → 1-(3,4-Diaminobenzyl)-4-methylpiperazine
Reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[N+:18]([O-])=O)[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]1)([O-])=O>CN(C=O)C.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[NH2:18])[CH2:7][N:8]1[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
1-(3,4-dinitrobenzyl)-4-methylpiperazine (1 g) was dissolved in DMF:MeOH (1:1, 20 mil) and agitated with 10% Pd/C (50 mg) under an atmosphere of H2 for 6 hours. The mixture was then filtered and evaporated to give a dark solid which was used immediately without any further purification.
Workup
- filtrationThe mixture was then filtered
- customevaporated
- customto give a dark solid which
- customwas used immediately without any further purification
Sources & evidence
- ORD record
- ord-a2ba3200f9484fc2bbba22790bad439b
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08399442B2
Reaction notes
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