Hydrazine → 6-(Propan-2-yl)-4,5-dihydropyridazin-3(2H)-one
Reaction equation
[CH3:1][CH:2]([CH3:10])[C:3](=O)[CH2:4][CH2:5][C:6](O)=[O:7].[NH2:11][NH2:12]>C(O)C>[CH:2]([C:3]1[CH2:4][CH2:5][C:6](=[O:7])[NH:11][N:12]=1)([CH3:10])[CH3:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Methyl-4-oxohexanoic acid (3.60 g, 25.0 mmol) and anhydrous hydrazine (0.80 g, 26.0 mmol) were heated for 3 hours in ethanol (36.0 ml) under stirring. After the reaction solution was concentrated under reduced pressure, hexane was added to the residues to precipitate crystals, and the crystals were collected by filtration to give 4,5-dihydro-6-isopropyl-3(2H)-pyridazinone as crystals. The yield was 3.10 g.
Workup
- concentrationAfter the reaction solution was concentrated under reduced pressure, hexane
- additionwas added to the residues
- customto precipitate crystals
- filtrationthe crystals were collected by filtration
Sources & evidence
- ORD record
- ord-89ea518887624acea03f3b30dd12e99f
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08399381B2
Reaction notes
Loading…