N-(2-methylpropyl)cyclopentanamine → 6-[cyclopentyl(isobutyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamide

HRID 1946765

Reaction equation

HRID 1946765 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][N:15]=[CH:14]3)=[O:9])[CH:3]=1.[CH:20]1([NH:25][CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:24][CH2:23][CH2:22][CH2:21]1>>[CH:20]1([N:25]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:2]2[N:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][C:11]3[CH:12]=[C:13]4[C:17](=[CH:18][CH:19]=3)[NH:16][N:15]=[CH:14]4)=[O:9])[CH:3]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 28428761N-(2-methylpropyl)cyclopentanamine2×HCID 594468806-chloro-N-1H-indazol-5-ylpyrimidine-4-carboxamide2×

Product 1

HCID 251829136-[cyclopentyl(isobutyl)amino]-N-1H-indazol-5-ylpyrimidine-4-carboxamideYield 78%

Procedure

Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (1H-indazol-5-yl)-amide (Intermediate 16) and cyclopentyl-isobutyl-amine (Intermediate 27), the title compound was obtained as a white solid in 78% yield.

Sources & evidence

ORD record
ord-f04eaf000c3c40008e9b64a7db8dcee4
Source dataset
uspto-grants-2013_03
Patent number
US08399448B2

Linked notes

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